“This project is part of the EDCTP2 programme supported by the European Union"

OUTCOMES

The DIAGMAL has had his kick off meeting in January 2020. At this moment all study sites are preparing the protocols that will be reviewed by their respective ethical committees before commencing the actual field evaluation.

The DIAGMAL project builds on past research. If you are interest in our previous work, you may find the following publications of interest:

1.  Roth, J.M., Sawa, P., Omweri, G., Makio, N., Osoti, V., Jong, M.D. de, Schallig, H.D.F.H. & Mens, P.F. (2018). Molecular detection of residual parasitemia after pyronardine-artesunate or artemether-lumefantrine treatment of uncomplicated Plasmodium faclciparum malaria in Kenyan children. American Journal of Tropical Medicine and Hygiene 99: 970-977. (see: http://www.ajtmh.org/docserver/fulltext/14761645/99/4/tpmd180233.pdf?expires=1583420041&id=id&accname=guest&checksum=D1ECBF81B8491B7FA541033334FE70C5)

2.   Roth, J.M., Sawa, P., Omweri, G., Osoti, V., Makio, N., Bradley, J., Bousema, T., Schallig, H.D.F.H. & Mens, P. (2018). Plasmodium falciparum gametocyte dynamics after Pyronaridine-artesunate or arthemether-lumefantrine treatment. Malaria Journal 17:223. (see: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987563/)

3.  Roth, J.M., Bes, L. de, Sawa, P., Omweri, G., Osoti, V., Oberheitmann, B., Schallig, H.D.F.H. & Mens, P.F. (2018). Plasmodium detection and differentiation by direct-on-blood PCR Nucleic Acid Lateral Flow Immunoassay: development, validation and evaluation. Journal of Molecular Diagnostics 20: 78-86. (see: https://www.sciencedirect.com/science/article/pii/S1525157817303513?via%3Dihub)

4.  Mens, P.F., Bes, M.H. de, Sondo, P., Loachan, N., Keereecharoen, L., Amerongen, A. van, Flint, J., Sak, J.R.S., Proux, S., Tinto, H. & Schallig, H.D.F.H. (2012). Direct blood PCR in combination with Nucleic Acid Lateral Flow Assay for the detection of Plasmodium species in settings where malaria is endemic. Journal of Clinical Microbiology 50: 3520-3525. (see: https://jcm.asm.org/content/50/11/3520.long)

5.  Mens, P.F., Moers, A., Bes, M.H. de, Flint, J., Sak, S.J.R., Keereecharoen, L., Overmeier, C. van, Verweijj, J.J., Hallett, R.L., Wihokhoen, B., Proux, S., Schallig, H.D.F.H & Amerongen, A. van. (2012). Development, validation and evaluation of a rapid PCR-Nucleic Acid Lateral Flow Immuno-Assay for the detection and differentiation of Plasmodium species. Malaria Journal: 279. (see: https://malariajournal.biomedcentral.com/articles/10.1186/1475-2875-11-279)

If you are interested in malaria microscopy and quality issues related to this, you may find the following Open Access publication of interest: Dhorda et al. Towards harmonization of microscopy methods for malaria clinical research studies Malaria Journal (2020) 19:324 (see: doi.org/10.1186/s12936-020-03352-z